MYCALOLIDE B

Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1It selectively and completely depolymerizes F-actin to G-actinviaa novel mechanism different from that of the cytochalasin D.2It is a novel and specific inhibitor of actomyosin ATPase.3

[1] SHUICHI SAITO. Mycalolide B, a novel actin depolymerizing agent.[J]. The Journal of Biological Chemistry, 1994, 38 1: 29710-29714. DOI:10.1016/s0021-9258(18)43938-5
[2] A. SUGIDACHI. Inhibition of Rat Platelet Aggregation by Mycalolide-B, a Novel Inhibitor of Actin Polymerization with a Different Mechanism of Action from Cytochalasin-D[J]. Thrombosis and haemostasis, 1998, 79 1: 614-619. DOI:10.1055/s-0037-1614955
[3] MASATOSHI HORI . Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge[J]. FEBS Letters, 1993, 322 2: Pages 151-154. DOI:10.1016/0014-5793(93)81557-g