2-Imino-4-methylpiperidine is a potent, general NOS inhibitor. It exhibits IC50 values of 0.1, 1.1, and 0.2 μM for inhibition of human iNOS, eNOS, and nNOS, respectively, at an arginine concentration of 30 μM.
A potent inhibitor of human iNOS (hNOS II).
2-Imino-4-methylpiperidine is a potent, general NOS inhibitor. It exhibits IC50 values of 0.1, 1.1, and 0.2 μM for inhibition of human iNOS, eNOS, and nNOS, respectively, at an arginine concentration of 30 μM.
Following oral administration, NOS-IN-1 (compound 3; 10 mg/kg) decreases serum nitrite/nitrate levels in an in vivo rat endotoxin assay[1].
[1] R. KEITH WEBBER. Substituted 2-Iminopiperidines as Inhibitors of Human Nitric Oxide Synthase Isoforms[J]. Journal of Medicinal Chemistry, 1998, 41 1: 96-101. DOI:
10.1021/jm9705059
