DEOXYLIMONIN

Desoxylimonin is an orally active triterpenoid compound found from grapefruit seed. Desoxylimonin shows anti-proliferative activities to breast cancer cells. Desoxylimonin derivatives shows better anticancer, analgesic and anti-inflammatory activity than the lead compound[1].

ChEBI: Desoxylimonin is a steroid lactone.

[1] Shaochi Wang, et al. Discovery of deoxylimonin δ-lactam derivative with favorable anti-inflammation and antinociception efficacy from chemical modified limonin/deoxylimonin analogs. Bioorg Chem. 2020 Jul;100:103886. DOI:10.1016/j.bioorg.2020.103886
[2] N. Guthri, et al. Inhibition of Human Breast Cancer Cells by Citrus Limonoids. ACS Symposium SeriesVol. 758, July 30, 2000.