UK 5099
UK 5099 性质
| 熔点 | 235-238°C |
|---|---|
| 沸点 | 448.6±45.0 °C(Predicted) |
| 密度 | 1.20 |
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：>20mg/mL |
| 酸度系数(pKa) | 1.49±0.19(Predicted) |
| 形态 | 粉末 |
| 颜色 | 黄色至棕褐色 |
| 稳定性 | 自购买之日起 1 年内保持稳定。 DMSO 或乙醇溶液可在 -20°C 下保存长达 1 个月。 |
| InChI | InChI=1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22) |
| InChIKey | BIZNHCWFGNKBBZ-JLHYYAGUSA-M |
| SMILES | C(O)(=O)C(C#N)=CC1C2=C(N(C3=CC=CC=C3)C=1)C=CC=C2 |
UK 5099 用途与合成方法
| Target | Value |
|
mitochondrial pyruvate carrier
() | 49 μM(Ki) |
The trypanosomal pyruvate carrier is found to be rather insensitive to inhibition by alpha-cyano-4-hydroxycinnamate (K i =17 mM) but can be completely blocked by UK-5099 (K i =49 microM). UK-5099 also inhibits the monocarboxylate transporter (MCT) . UK5099 significantly inhibits the glucose-stimulated rise in oxygen consumption in a dose-dependent manner and at 150 μM reduced oxygen consumption below basal levels. UK5099 reduces ATP levels and increases ADP and AMP levels in 832/13 cells. The UK5099 treated cells show significantly higher proportion of side population fraction and express higher levels of stemness markers Oct3/4 and Nanog. UK5099 application may be an ideal model for Warburg effect studies.
The MPC inhibitor UK5099 increases the glucose excursion seen during an intraperitoneal glucose tolerance test in C57BLK mice.
UK 5099 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-15475 | UK 5099 | 56396-35-1 | 5mg | 650 |
| 2026-09-15 | HY-15475 | UK 5099 | 56396-35-1 | 10mM * 1mLin DMSO | 715 |
