Z-Val-DL-Asp-fluoromethylketone

Chemical Properties

Boiling point	639.8±55.0 °C(Predicted)
Density	1.258±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 10 mg/ml
form	A solid
pka	3.92±0.19(Predicted)
color	White to off-white

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Animal Model:	Female ND4 Swiss Webster mice (16.5-21 g)^[1]
Dosage:	0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mmTris-HCl, pH 8.0)
Administration:	Injected i.v.
Result:	The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kgdose protected 100% of the mice at the 3 h time point.