Uses
MX1013 is a potent, irreversible dipeptide caspase inhibitor vithantiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50of 30 nM[1].
in vivo
MX1013 is an effective antiapoptotic agentin vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects[1].
| Animal Model: | Female ND4 Swiss Webster mice (16.5-21 g)[1] |
| Dosage: | 0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mmTris-HCl, pH 8.0) |
| Administration: | Injected i.v. |
| Result: | The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kgdose protected 100% of the mice at the 3 h time point.
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References
[1] Wu Yang,et al. MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity. Br J Pharmacol.2003 Sep;140(2):402-12. DOI:
10.1038/sj.bjp.0705450
