1-Propanone, 1,3-bis(2,4-dihydroxyphenyl)-

Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1].

[1] Songtao Xue, et al. Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation. J Med Chem. 2023 Apr 13;66(7):5099-5117. DOI:10.1021/acs.jmedchem.3c00012