Gatifloxacinacid

Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml)[1]. Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

Gatifloxacin hydrochloride (AM-1155 hydrochloride) is a potent fluoroquinolone antibiotic with broad-spectrum antimicrobial activity.

Quinolone; Topoisomerase II: 36.7 μM ()

[1] Takei M, et al. Inhibitory activities of Gatifloxacin hydrochloride (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases.Antimicrob Agents Chemother.1998 Oct;42(10):2678-81. DOI:10.1128/AAC.42.10.2678
[2] Fukuda H, et al. Antibacterial activity of Gatifloxacin hydrochloride (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob Agents Chemother.1998 Aug;42(8):1917-22. DOI:10.1128/AAC.42.8.1917
[3] Yamada C, et al. Gatifloxacin hydrochlorideacutelystimulatesinsulinsecretionandchronicallysuppressesinsulinbiosynthesis. Eur J Pharmacol.2006 Dec 28;553(1-3):67-72. Epub 2006 Sep 28. DOI:10.1016/j.ejphar.2006.09.043
[4] Daw-Garza A, et al. InvivotherapeuticeffectofGatifloxacin mesylateonBALB/cmiceinfectedwithNocardiabrasiliensis.Antimicrob Agents Chemother.2008 Apr;52(4):1549-50. DOI:10.1128/AAC.00148-08