White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the fruit of Solanum aviculare Forst.
α-Solamargine is a steroidal glycosyl-alkaloid which displays inactivation of PI3-L/Akt and reduction for SP1 and p65 in the suppression of human lung cancer cells.
ChEBI: Solamargine is an azaspiro compound, a steroid and an oxaspiro compound.
Solamargine (10 mg/kg; intragastric administration; once daily for 8 days) exhibits an antitumor effect and promotes the apoptosis of GC in vivo[4].
| Animal Model: | Female specific pathogen-free BALB/c nude mice weighing 18-20 g (6-8-weeks-old)[4] |
| Dosage: | 10 mg/kg |
| Administration: | Intragastric administration; once daily for 8 days
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| Result: | Tumor growth was significantly inhibited .
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