Platinate(2-), [(1R,2R)-1,2-cyclohexanediamine-κN1,κN2][diphosphato(4-)-κO,κO'']-, hydrogen (1:2), (SP-4-2)-

Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity[1][2][3].

[1] Moghaddas S, et, al. Phosphaplatins, next generation platinum antitumor agents: A paradigm shift in designing and defining molecular targets. Inorganica Chimica Acta. 2012 Dec; 393(1): 173-181.
[2] Yamazaki T, et al. PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models. Oncoimmunology. 2020 Feb 11;9(1):1721810. DOI:10.1080/2162402X.2020.1721810
[3] Soler-Agesta R, et al. PT-112 induces mitochondrial stress and immunogenic cell death, targeting tumor cells with mitochondrial deficiencies[J]. Cancers, 2022, 14(16): 3851. DOI:10.3390/cancers14163851