1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells[1].

NF-κB-IN-1, a 4-arylene curcumin analog, is a potent NF-κB signaling pathway inhibitor. It directly inhibits IKK to block NF-κB activation. It can effectively inhibit the viability of lung cancer cells and attenuate the clonal activity of A549 cells.

NF-κB-IN-1 (compound 17) (0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI ₅₀ s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.

[1] Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73. DOI:10.1021/jm1004545