名称 | NF-κB-IN-1 |
描述 | NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells. |
体外活性 | NF-κB-IN-1 (0.5-25 μM; pretreated for 30 min or 4 h) potently blocks the IκB phosphorylation and degradation in A549 cells.It(0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI50s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.NF-κB-IN-1 (0.1-0.4 μM; 9 d) inhibits lung cancer clonogenic activity. NF-κB-IN-1 (0.1-100 μM; pretreated for 30 min) dose-dependently inhibits the TNFα-induced nuclear translocation of NF-κB in A549 cells, with an IC50s of 1.0 μM[1]. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 40 mg/mL (75.39 mM), Sonication is recommended.
|
关键字 | pathway | 4-arylidene | Inhibitor | inhibit | NF-kB-IN-1 | IKK | crucumin | cancer | A549 | NFκBIN1 | I kappa B kinase | signaling | NF κB IN 1 | NF-kappaB-IN-1 | IκB kinase | NF-κB | NF-κB-IN-1 |
相关产品 | Amlexanox | Sodium Houttuyfonate | Lidocaine | Diethylmaleate | Resveratrol | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | 5-Aminosalicylic Acid | Indole-3-carbinol | Diallyl disulfide | Sodium salicylate |
相关库 | 抗肺癌化合物库 | 经典已知活性库 | 激酶抑制剂库 | 抗卵巢癌化合物库 | 抑制剂库 | NO PAINS 化合物库 | 抗衰老化合物库 | 已知活性化合物库 | 抗肝癌化合物库 | 抗癌活性化合物库 |