(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1].
| Animal Model: | Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1] |
| Dosage: | 25 mg/kg, 50 mg/kg |
| Administration: | Oral gavage; daily; for 3 weeks |
| Result: | The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.
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