Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt

Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.1,2 It is nonphosphorylatable and selective for CaMKII over PKC, PKA and CaMKIV (IC50s > 10 μM).1,2 This compound is a useful tool for studying the physiological roles of CaMKII.3WARNING This product is not for human or veterinary use.

[1] ISHIDA A. A Novel Highly Specific and Potent Inhibitor of Calmodulin-Dependent Protein Kinase II[J]. Biochemical and biophysical research communications, 1995, 212 3: Pages 806-812. DOI: 10.1006/bbrc.1995.2040
[2] A ISHIDA  H F. Stabilization of calmodulin-dependent protein kinase II through the autoinhibitory domain.[J]. The Journal of Biological Chemistry, 1995, 270 5: 2163-2170. DOI: 10.1074/jbc.270.5.2163
[3] S TAKASAWA. Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization.[J]. The Journal of Biological Chemistry, 1995, 270 51: 30257-30259. DOI: 10.1074/jbc.270.51.30257