PACAP-related Peptide (rat) (trifluoroacetate salt)

PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin (Item No. 24561), glucagon (Item No. 24204), glucagon-like peptide-1 (GLP-1; Item No. 24460), GLP-2 (Item No. 24414), and pituitary adenylate cyclase-activating polypeptide (PACAP; Item Nos. 24769 | 24770).1,2 It is expressed in rat hypothalamus as well as within the nerves of the median eminence, the anterior pituitary, bed nucleus of the stria terminalis, cerebellum, cerebral cortex, and amygdala.3,4 PRP is also expressed in vaginal, uterine cervical, uterine horn, fallopian tube, and ovarian tissues from the rat female genital tract and is present in extracts of male testis tissue.5,6WARNING This product is not for human or veterinary use.

[1] DAVID VAUDRY. Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.[J]. Pharmacological Reviews, 2009, 61 3: 283-357. DOI: 10.1124/pr.109.001370
[2] JANICE K.V. TAM  Billy K C C  Leo T O Lee. PACAP-related peptide (PRP)—Molecular evolution and potential functions[J]. Peptides, 2007, 28 9: Pages 1920-1929. DOI: 10.1016/j.peptides.2007.07.011
[3] J. HANNIBAL . Gene expression of pituitary adenylate cyclase activating polypeptide (PACAP) in the rat hypothalamus[J]. Regulatory Peptides, 1995, 55 2: Pages 133-148. DOI: 10.1016/0167-0115(94)00099-j
[4] JENS D. MIKKELSEN. Pituitary Adenylate Cyclase Activating Peptide-38 (PACAP-38), PACAP-27, and PACAP Related Peptide (PRP) in the Rat Median Eminence and Pituitary[J]. Journal of Neuroendocrinology, 1995, 7 1: 47-55. DOI: 10.1111/j.1365-2826.1995.tb00666.x
[5] J. FAHRENKRUG  J. H. Pituitary adenylate cyclase activating polypeptide innervation of the rat female reproductive tract and the associated paracervical ganglia: Effect of capsaicin[J]. Neuroscience, 1996, 73 4: Pages 1049-1060. DOI: 10.1016/0306-4522(96)00082-6
[6] J. HANNIBAL  J. F. Expression of pituitary adenylate cyclase activating polypeptide (PACAP) gene by rat spermatogenic cells[J]. Regulatory Peptides, 1995, 55 1: Pages 111-115. DOI: 10.1016/0167-0115(94)00110-j