甲磺酸阿米三嗪
甲磺酸阿米三嗪 用途与合成方法
甲磺酸阿米三嗪别称二甲磺酸阿米三嗪，其主要通过阿米三嗪发挥其药理作用。阿米三嗪作用于颈动脉体化学感受器，兴奋呼吸，从而加强肺泡-毛细血管的气体交换，增加动脉氧分压和血氧饱和度，从而使脑功能得到改善和加强。
甲磺酸阿米三嗪主要用于亚急性和慢性脑血管机能不全、脑猝中风后遗症、老年性轻、中度痴呆和良性记忆障碍及缺血性耳蜗前庭功能失调等。
Almitrine mesylate 是一种外周化学感受器的激动剂，选择性抑制 Ca2+依赖性的 K+ 通道。K + channel
Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca 2+ -dependent K + channel by decreasing its open probability. The IC 50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca 2+ -dependent K + channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K + , Ca 2+ , or Na + currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca 2+ -dependent component of K + currents in rat chemoreceptor cells.
Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio.
甲磺酸阿米三嗪 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-107319 | 甲磺酸阿米三嗪 | 29608-49-9 | 5 mg | 100 |
| 2026-09-15 | HY-107319 | 甲磺酸阿米三嗪 | 29608-49-9 | 10 mM * 1 mL in DMSO | 147 |
