After adding 2,4-dibromofluorobenzene (20.0 g, 0.08 mol, 1 eq.) and anhydrous DMF (350 mL) to a 500 mL round-bottomed flask, sodium methanol (5.2 g, 0.09 mol, 1.2 eq.) was slowly added to the round-bottomed flask with vigorous stirring at room temperature overnight, and then the reaction was neutralized by the addition of 5% HCl to stop the reaction.The reaction was extracted by CH2Cl2 ( 50 mL??3), the organic phase was washed with distilled water (50 mL??3), and the organic phase was dried by anhydrous magnesium sulfate. CH2Cl2 extraction ( 50mL??3), the organic phase was washed with distilled water (50mL??3), anhydrous magnesium sulfate drying organic phase, filtration to remove magnesium sulfate, spinning to remove the solvent to get a light yellow solid, silica gel chromatography column purification (eluent: petroleum ether), to get a white solid 30g, yield 95%.
