Phthalamic Acid is a reactant in the synthesis of phthalimide derivatives with analgesic activity.
Phthalamic acid may be used to synthesize anthranilic acid via reaction with sodium hypochlorite.
ChEBI: 2-carbamoylbenzoic acid is a carbamoylbenzoic acid.
Phthalamic acid can be synthesized from the reaction between ammonia and phthalic anhydride by a modified Auger′s method. Kinetic studies of the intramolecular carboxylic-group assisted hydrolysis of amide bond of phthalamic acid provided the value of pseudo-first order rate constant (kobs) as 5.1×10-5sec-1 at pH 1.3-1.8 and 35°C. It undergoes hydrolysis about 105 times faster than benzamide.
