2',5'-DIDEOXYADENOSINE
2',5'-DIDEOXYADENOSINE
2',5'-DIDEOXYADENOSINE 性质
| 沸点 | 547.0±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.77±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 可溶于DMSO |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.06±0.60(Predicted) |
| 颜色 | 白色 |
2',5'-DIDEOXYADENOSINE 用途与合成方法
IC50: 3 µM (adenylyl cyclase)
2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448.
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.
Western Blot Analysis
| Cell Line: | Primary hippocampal neurons |
| Concentration: | 10 μM |
| Incubation Time: | 30 min |
| Result: | Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh). |
2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K
+
and Cl
-
sparing effect of Fr•EtOAc in rats.
| Animal Model: | Male Wistar rats (3-4 months old) |
| Dosage: | 0.1 mg/kg |
| Administration: | IP; 15 min pre-treated |
| Result: | Fully inhibited the diuretic, natriuretic and K + and Cl - sparing effect of Fr•EtOAc in rats. |
2',5'-DIDEOXYADENOSINE 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-135878 | 1 mg | 431 | ||
| 2024-11-08 | HY-135878 | 2',5'-DIDEOXYADENOSINE | 6698-26-6 | 5mg | 950 |
