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3-Aminobenzamide

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3-Aminobenzamide Basic information
3-Aminobenzamide Chemical Properties
  • Melting point:115-116 °C (lit.)
  • Boiling point:250.42°C (rough estimate)
  • Density 1.1778 (rough estimate)
  • refractive index 1.5769 (estimate)
  • storage temp. room temp
  • solubility ethanol: 50 mg/mL, clear, faintly yellow
  • form powder
  • pka16.26±0.50(Predicted)
  • color white to off-white
  • Water Solubility Soluble in dimethylformamide (~30 mg/ml), dimethyl sulfoxide (~30 mg/ml), phosphate buffered saline (pH7.2) (~2 mg/ml), water (25 mg/ml), and ethanol (25 mg/ml).
  • Sensitive Light Sensitive
  • BRN 2802373
  • CAS DataBase Reference3544-24-9(CAS DataBase Reference)
  • NIST Chemistry Reference3-NH2-C6H4CONH2(3544-24-9)
Safety Information
MSDS
3-Aminobenzamide Usage And Synthesis
  • DescriptionThe poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.
  • Chemical Propertiesbeige powder
  • UsesThe poly(ADP-ribose) polymerases (PARPs) comprise a family of enzymes which post-translationally modify proteins by poly(ADP-ribosyl)ation. Since some PARPs are activated by DNA strand breaks, PARP signaling has roles in DNA repair, apoptosis, inflammation, and other cellular responses. 3-amino Benzamide is an inhibitor of PARPs (Ki = 1.8 μM). Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It has PARP-mediated actions in such diverse diseases as atherosclerosis, neurogenesis, and cancer.
  • Uses3-Aminobenzamide is used as an endogenous poly-ADP-ribosyltransferase inhibitor. Through its effects on PARPs, 3-amino benzamide causes telomere shortening and stimulates angiogenesis. It displays neuroprotective, anti-necrotic effects.
  • DefinitionChEBI: A substituted aniline that is benzamide in which one of the meta- hydrogens is replaced by an amino group.
  • Biochem/physiol Actions3-Aminobenzamide enhances cell death, unscheduled DNA synthesis and repair replication by interrupting the rejoining of DNA strand breaks induced by both ionizing radiations and several alkylating agents. It has an ability to inhibit the activity of nuclear enzyme poly (ADP-ribose) synthetase (PARS). 3-Aminobenzamide exhibits protective action against myocardial reperfusion injury and local inflammation.
3-Aminobenzamide Preparation Products And Raw materials
3-Aminobenzamide(3544-24-9)Related Product Information
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