Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension[1].

Cell permeable: yes', 'Primary Target
Soluble epoxide hydrolase', 'Product competes with ATP.', 'Reversible: no', 'Target IC50: 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH

[1] Imig JD,et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.Hypertension. 2002 Feb;39(2 Pt 2):690-4. DOI:10.1161/hy0202.103788