2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)-

Chemical Properties

Boiling point	457.2±45.0 °C(Predicted)
Density	1.291±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	12.34±0.20(Predicted)
form	Solid
color	Yellow to orange
InChI	InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
InChIKey	YKQONSWBHGBDSB-XFXZXTDPSA-N
SMILES	N1C2=C(C=CC=C2)/C(=C/C2=NC=CC=C2)/C1=O

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Animal Model:	HFD+STZ diabetic rats ^[1].
Dosage:	50 mg/kg
Administration:	i.p., 30 min prior to glucose challenge
Result:	Vehicle-treated diabetic rats developed persistent hyperglycemic response. Administration of GSK-3β inhibitor 1 30 min prior to glucose challenge effectively prevented increase in blood glucose levels.