Ampreloxetine (0.3, 1, 5, 10, 30, 60 mg/kg; p.o.; single dose) shows a plasma EC50s of 11.7ng/mL and 50.8ng/mL in rat, respectively[1].
| Animal Model: | Male Sprague Dawley rats[1] |
| Dosage: | 0.3, 1, 5, 10, 30, 60 mg/kg |
| Administration: | P.o.; single dose |
| Result: | Showed good PK and PD parameter with Emax of 79%, 92% for SERT and NET, respectively; EC50 values of 50.8, 11.7 ng/mL for SERT, NET, respectively. |
