DERMASEPTIN PHYLLOMEDUSA SAUVAGII

Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity againstbacteria,fungi, and protozoaat micromolar concentration[1].

Dermaseptin is a polypeptide isolated from frog skin that exhibits potent antimicrobial activity against bacteria, fungi and protozoa.

Dermaseptin is a water-soluble, thermostable, and nonhemolytic peptide endowed with highly potent antimicrobial activity against pathogenic fungi at micromolar concentration.

Dermaseptin is derived from insect antimicrobial peptides; mammalian antimicrobial peptides; amphibian antimicrobial peptides; fish, mollusk and crustacean derived antimicrobial peptides; plant antimicrobial peptides and bacterial antimicrobial peptides.

[1] Mor A, et al. Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin. Biochemistry. 1991 Sep 10;30(36):8824-30. DOI:10.1021/bi00100a014
[2] Mor A, et al. The NH2-terminal alpha-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity. J Biol Chem. 1994 Jan 21;269(3):1934-9. PMID:8294443