Uses
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity againstbacteria,fungi, and protozoaat micromolar concentration[1].
Biological Activity
Dermaseptin is a polypeptide isolated from frog skin that exhibits potent antimicrobial activity against bacteria, fungi and protozoa.
in vitro
Dermaseptin is a water-soluble, thermostable, and nonhemolytic peptide endowed with highly potent antimicrobial activity against pathogenic fungi at micromolar concentration.
Source
Dermaseptin is derived from insect antimicrobial peptides; mammalian antimicrobial peptides; amphibian antimicrobial peptides; fish, mollusk and crustacean derived antimicrobial peptides; plant antimicrobial peptides and bacterial antimicrobial peptides.
References
[1] Mor A, et al. Isolation, amino acid sequence, and synthesis of dermaseptin, a novel antimicrobial peptide of amphibian skin. Biochemistry. 1991 Sep 10;30(36):8824-30. DOI:
10.1021/bi00100a014[2] Mor A, et al. The NH2-terminal alpha-helical domain 1-18 of dermaseptin is responsible for antimicrobial activity. J Biol Chem. 1994 Jan 21;269(3):1934-9. PMID:8294443
