WHITE TO ALMOST WHITE POWDER
Clinium,Janssen,W. Germany,1969
Lidoflazine is a L-type Ca2+ channel antagonist.Also, it is derived from 1,1''-(4-Chlorobutylidene)bis(4-fluorobenzene) (C364775), which is a derivative of Zerumbone with potential anti-tumor effects towards HeLa cancer cells.
Coronary vasodilatator;Ca++ channel activator
ChEBI: 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide is a diarylmethane.
A mixture of 6.6 parts 1-[4,4-di-(4-fluoro-phenyl)butyl]-piperazine, 4.33 parts
N-(2-chloro-acetyl)-2,6-dimethyl-aniline, 3.2 parts sodium carbonate, a few
crystals of potassium iodide in 200 parts 4-methyl-2-pentanone is stirred and
refluxed for 70 hours. After cooling there are added 70 parts water. The
organic layer is separated, dried over potassium carbonate, filtered and
evaporated. The oily residue is dissolved in 80 parts diisopropylether and the
solution is filtered hot. After cooling the filtrate at 0°C. the formed solid is
filtered off and recystallired from 80 parts ether, yielding 1-[4,4-di-(4-fluorophenyl)butyl]-4-[(2,6-dimethylanilino-carbonyl)-methyl]-piperazine; MP 159°C
to 161°C.
Angex (Janssen);
Clinium (Ortho-McNeil).
