The preparation of O-Methyl-undecaethylene glycol is as follows: 30% ethylene oxide aqueous solution and 0.2% potassium hydroxide aqueous solution are respectively introduced into a mixer and mixed, with water as the initiator. The microchannel reactor has a diameter of 200 micrometers and a length of 2 meters. The system temperature is 100℃, the reaction pressure is 2.0 atm, and the reaction time is 5 min. The reaction is terminated by adding 0.2% hydrochloric acid in a terminator. After filtration, decolorization, and solvent removal, oligoethylene glycol is obtained with a number average molecular weight of 450, a degree of polymerization of about 10, and a dispersion of 1.0.