UPGL00004

Product NameUPGL00004
CAS1890169-95-5
MFC25H26N8O2S2
MW534.66
EINECS
MOL File1890169-95-5.mol

Chemical Properties

Density	1.460±0.06 g/cm3(Predicted)
pka	9.23±0.50(Predicted)
form	Solid
color	Off-white to gray

Usage And Synthesis

Biological Activity

UPGL00004 is a potent glutaminase C (GAC) inhibitor with IC50 of 29 nM, more selective for GAC than GLS2.

in vitro

Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab effectively inhibited triple-negative breast cancer cell growth and tumor growth.

in vivo

Administration of UPGL00004 in combination with the anti-VEGF antibody bevacizumab inhibited tumor growth in a human xenograft model of breast cancer.

target

< td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 29 nM