1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
英文名称:1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide
CAS号:1610022-76-8
分子式:C21H22ClN3O2
分子量:383.87
EINECS号:
Mol文件:1610022-76-8.mol
![1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide 结构式](https://img.chemicalbook.com/CAS/20180527/GIF/1610022-76-8.gif)
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide 性质
密度 | 1.23±0.1 g/cm3(Predicted) |
---|---|
储存条件 | Store at -20°C |
溶解度 | 二甲基亚砜:260 mg/mL(677.31 mM) |
形态 | 固体 |
酸度系数(pKa) | 8.44±0.50(Predicted) |
颜色 | 白色至米白色 |
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide 用途与合成方法
Nrf2-IN-1 是 Nrf2 的抑制剂,被用于急性髓性白血病 (AML) 药物研究。
Nrf2
Nrf2-IN-1 (Compound 4f) (10 μM) inhibits Nrf2 activation.
Nrf2-IN-1(1-20 μM; 48 hours) inhibits growth of the three AML cell.
Nrf2-IN-1 (5-10 μM; 48 hours) induces apoptosis of three AML cells in vitro.
Nrf2-IN-1 induces apoptotic signaling involving Bcl-2 and Bax.
Cell Viability Assay
Cell Line: | THP-1 cells, HL-60 cells, U937 cells |
Concentration: | 1 μM, 5 μM, 10 μM, 20 μM |
Incubation Time: | 48 hours |
Result: | Inhibited growth of the three AML cell types at 5 μM, 10 μM or 20 μM for 48 hours. |
Apoptosis Analysis
Cell Line: | THP-1 cells, HL-60 cells, U937 cells |
Concentration: | 5 μM, 10 μM |
Incubation Time: | 48 hours |
Result: | Induced apoptosis in AML cells in vitro. |
Western Blot Analysis
Cell Line: | THP-1 cells, HL-60 cells, U937 cells |
Concentration: | 5 μM, 10 μM |
Incubation Time: | 48 hours |
Result: | Triggered caspase-dependent apoptotic signaling in AML cells. |
Nrf2-IN-1 inhibits tumor growth via apoptosis in chicken eggs.
1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)-N-hydroxy-1H-pyrazole-5-carboxamide供应商 更多
上海奥晨生物医药科技有限公司
联系电话: 13917627064
产品介绍:
英文名称:1-(4-(tert-butyl)benzyl)-3-(4-chlorophenyl)
CAS:1610022-76-8
纯度:95%
包装信息:1g,5g
备注:现货
ChemeGen 中国
联系电话: 18818260767
产品介绍:
英文名称:Nrf2 inhibitor 1
CAS:1610022-76-8
纯度:98%
包装信息:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
备注:品牌:ChemeGen
成都超九八生物科技有限公司
联系电话:13348960310 13348960310
产品介绍:
英文名称:Nrf2-IN-1
CAS:1610022-76-8
纯度:98%
包装信息:5mg;10mg;20mg;50mg;100mg;200mg
天津普西唐生物医药科技有限公司
联系电话:010-60605840 15801484223;
产品介绍:
英文名称:Nrf2-IN-1
CAS:1610022-76-8
纯度:98%
包装信息:5mg;10mg;50mg;100mg