AdipotideTM, or Prohibitin-Targeting Peptide 1 (Prohibitin-TP01), is an anti-obesity peptide that specifically targets and kills blood vessels supplying white fat tissue. It is the peptidomimetic CKGGRAKDC-GG-D(KLAKLAK)2. Adipotide targeted the vasculature of white adipose tissue and resulted in ~30% weight reduction in obese mice over a period of 4 weeks. Therefore, unlike nonspecific angiogenesis inhibitors, adipokine is systemically targeted to the endothelium of fat through a ligand-directed mechanism and disrupts the vascular supply of white adipose tissue, at least in rodent obesity models. Moreover, an annexin A2–prohibitin receptor system targeted by adipotide has been reported recently in the white adipose tissue vasculature of human patients[1].
