H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 用途与合成方法
Paracellular permeability
Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.
When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH | 881851-50-9 | 1mg | 700 |
| 2024-11-08 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH | 881851-50-9 | 5mg | 1100 |
