H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 性质
| 熔点 | >231°C (dec.) |
|---|---|
| 储存条件 | Refrigerator |
| 溶解度 | 可微溶于水 |
| 形态 | 固体 |
| 颜色 | 白色 |
| InChIKey | NYGCNONRVCGHAT-FTIBEKKFNA-N |
| SMILES | C(O)(=O)C.C(O)(=O)CNC([C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(CNC(CN)=O)=O)C(C)C)CC(C)C)C(C)C)CCC(N)=O)=O |&1:10,17,21,25,29,r| |
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 用途与合成方法
Paracellular permeability
Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.
When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025-12-22 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH | 881851-50-9 | 1mg | 586 |
| 2025-12-22 | HY-106268A | H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH | 881851-50-9 | 5mg | 997 |
