生物活性 靶点 体外研究 体内研究 H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 试剂级价格
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ChemicalBook  CAS数据库列表  H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH

H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH

生物活性 靶点 体外研究 体内研究 H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 试剂级价格
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH,881851-50-9,结构式
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
  • CAS号:881851-50-9
  • 英文名:Larazotide
  • 中文名:H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH
  • CBNumber:CB03054563
  • 分子式:C34H59N9O12
  • 分子量:785.88536
  • MOL File:881851-50-9.mol
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH化学性质
  • 熔点 :>231°C (dec.)
  • 储存条件 :Refrigerator
  • 溶解度 :Water (Slightly)
  • 形态 :Solid
  • 颜色 :White

H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH性质、用途与生产工艺

  • 生物活性 Larazotide acetate 是一种合成肽，是一种紧密连接 (junction) 的调节剂。
  • 靶点

    Paracellular permeability

  • 体外研究

    Larazotide acetate inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Further, apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.

  • 体内研究

    When tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice, larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure.

H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH上下游产品信息
上游原料
下游产品
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH 试剂级价格
  • 更新日期：2024/11/08
  • 产品编号：HY-106268A
  • 产品名称：H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate
  • CAS编号：881851-50-9
  • 包装：1mg
  • 价格：700元
  • 更新日期：2024/11/08
  • 产品编号：HY-106268A
  • 产品名称：H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH Larazotide acetate
  • CAS编号：881851-50-9
  • 包装：5mg
  • 价格：1100元
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