6-Hydroxy-1-tetralone

Product Name6-Hydroxy-1-tetralone
CAS3470-50-6
MFC10H10O2
MW162.19
EINECS
MOL File3470-50-6.mol

Chemical Properties

Melting point	154-157 °C(lit.)
Boiling point	358.0±31.0 °C(Predicted)
Density	1.236±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	8.22±0.20(Predicted)
form	Crystalline Powder
color	Off-white to brown
InChIKey	FNSQPQKPPGALFA-UHFFFAOYSA-N
CAS DataBase Reference	3470-50-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29145090

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Chemical Properties

gray powder

Uses

6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) may be used in the synthesis of:

5-chloromethyl-6-hydroxy-3,4-dihydro-1(2H)-naphthalenone
6-(4-(3-(piperidin-1-yl)propoxy)benzyloxy)-1-tetralone
6-(3-(piperidin-1-yl)propoxy)-1-tetralone

Uses

6-Hydroxy-1-tetralone is used as a starting material for a one-pot conversion of phenols to anilines.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 41, p. 1068, 1998 DOI: 10.1021/jm970527v
Journal of the American Chemical Society, 99, p. 5810, 1977 DOI: 10.1021/ja00459a052

General Description

6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) can be prepared by the demethylation of 6-methoxy-3,4-dihydro-1(2H)-naphthalenone. It participates in the synthesis of 2-alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols. Its pKa value has been reported to be 7.74.

Preparation Products And Raw materials

Raw materials

7-Hydroxy-1-tetralone

Preparation Products

6-CYANO-1-TETRALONE 6-(benzyloxy)-3,4-dihydronaphthalen-1(2H)-one 3-(((5-OXO-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)OXY)METHYL)BENZONITRILE 1-Naphthalenol, 2-bromo-1,2,3,4-tetrahydro-6-(phenylmethoxy)-1(2H)-Naphthalenone, 6-[(4-bromophenyl)methoxy]-3,4-dihydro-1(2H)-Naphthalenone, 3,4-dihydro-6-[(4-iodophenyl)methoxy]-1(2H)-Naphthalenone, 6-[(4-fluorophenyl)methoxy]-3,4-dihydro-