6-Hydroxy-1-tetralone

Chemical Properties

gray powder

Uses

6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) may be used in the synthesis of:

• 5-chloromethyl-6-hydroxy-3,4-dihydro-1(2H)-naphthalenone
• 6-(4-(3-(piperidin-1-yl)propoxy)benzyloxy)-1-tetralone
• 6-(3-(piperidin-1-yl)propoxy)-1-tetralone

Uses

6-Hydroxy-1-tetralone is used as a starting material for a one-pot conversion of phenols to anilines.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 41, p. 1068, 1998 DOI: 10.1021/jm970527v
Journal of the American Chemical Society, 99, p. 5810, 1977 DOI: 10.1021/ja00459a052

General Description

6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) can be prepared by the demethylation of 6-methoxy-3,4-dihydro-1(2H)-naphthalenone. It participates in the synthesis of 2-alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols. Its pKa value has been reported to be 7.74.