Sphingosine (d12:1) is a short-chain sphingolipid. It decreases serine palmitoyltransferase activity in primary cultured mouse cerebellar cells in a concentration-dependent manner. Sphingosine (d12:1) (0.5-50 μM) decreases production of sphingosine (d18:1) , lactosylceramide (Item Nos. 27197 | 16983), galactosylceramide , and a variety of gangliosides in mouse cerebellar granule cells. [Matreya, LLC. Catalog No. 1838]
(2S,3R,4E)-2-Amino-4-dodecene-1,3-diol acts as a sphingolipid base that inhibits sphingosine kinase.
