Description
Sphingosine (d12:1) is a short-chain sphingolipid. It decreases serine palmitoyltransferase activity in primary cultured mouse cerebellar cells in a concentration-dependent manner. Sphingosine (d12:1) (0.5-50 μM) decreases production of sphingosine (d18:1) , lactosylceramide (Item Nos.
27197 |
16983), galactosylceramide , and a variety of gangliosides in mouse cerebellar granule cells. [Matreya, LLC. Catalog No. 1838]
Uses
(2S,3R,4E)-2-Amino-4-dodecene-1,3-diol acts as a sphingolipid base that inhibits sphingosine kinase.
References
[1] E C MANDON. Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases.[J]. European journal of biochemistry, 1991, 198 3: 667-674. DOI:
10.1111/j.1432-1033.1991.tb16065.x[2] G. ECHTEN. Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases.[J]. The Journal of Biological Chemistry, 1990, 120 1: 9333-9339. DOI:
10.1016/s0021-9258(19)38853-2
