基本属性 生物活性体外研究 用途与合成方法 供应商
网站主页 > 化工产品目录 >生物化工 > 抑制剂 > 神经信号通路(Neuronal Signaling) > P2 Receptor 抑制剂 > GW791343 HCl

GW791343 HCl

基本属性 生物活性体外研究 用途与合成方法 供应商
GW791343 HCl
GW791343 HCl 用途与合成方法
  • 生物活性GW791343 HCl是GW791343的盐酸盐形式,是一种非竞争性的人类P2X7 receptor变构抑制剂,pIC50为7。
  • 体外研究In cells expressing human P2X7 receptors, GW 791343 inhibits agonist-stimulated ethidium accumulation in both sucrose and NaCl buffer. In NaCl buffer, GW 791343 reduces the maximal response to both ATP and BzATP, but there is little effect on agonist potency except for a decrease in the presence of 300–1000 nM GW 791343. GW 791343 also reduces maximal responses to ATP and BzATP in sucrose buffer, although this effect is more marked when using ATP as agonist. In sucrose buffer, GW 791343 produces a slight decrease in ATP potency at 300 nM. GW 791343 decreases BzATP potency at concentrations of 300 nM to 10 μM. A more marked increase in agonist effect is observed when using ATP as agonist in NaCl buffer with GW791343 increasing the pEC50 and maximal response to ATP at concentrations of 10 and 30 μM. In sucrose buffer, GW791343 also increases responses when using ATP as agonist. GW791343 inhibits responses at the human–rat chimeric receptor in both sucrose and NaCl buffer. GW791343 increases responses to BzATP at the F95L mutant receptor. GW791343 is a non-competitive antagonist and negative allosteric modulator at the human P2X7 receptor; however, GW 791343 also acts as a positive allosteric modulator at the rat P2X7 receptor. At the dog P2X7 receptor, GW 791343 is an antagonist with similar potency to that determined at the human receptor.
GW791343 HCl供应商更多
  • 公司名称:Wuhan NCE Biomedical Co.,Ltd.
  • 联系电话:4000-027-021 |24 hour enquiry :+86-13986109188 |English:+86-15623472865 |Japanese:+81-08033611988
  • 产品介绍: 英文名称:GW 791343 HCl
    CAS:309712-55-8
    纯度:99% HPLC 包装信息:50Mg,100Mg,500Mg,1g,5g,10g,50g,100g,500g,1kg 备注:XYA0318
  •  
  • 公司名称:上海阿拉丁生化科技股份有限公司
  • 联系电话:021-20337333/400-620-6333
  • 产品介绍: 英文名称:GW791343 HCl
    CAS:309712-55-8
    纯度:99% 包装信息:4692RMB/10MG 备注:试剂级
  •  
  • 公司名称:MedChemexpress LLC
  • 联系电话:609-228-6898
  • 产品介绍: 英文名称:GW791343 (trihydrochloride)
    CAS:309712-55-8
    纯度:>98% 包装信息:990RMB/5mg 备注:试剂级
  •  
  • 公司名称:济南铭雅医药科技有限公司
  • 联系电话:+86-531-85828981 18866807006
  • 产品介绍: 英文名称:GW 791343 hydrochloride
    CAS:309712-55-8
    纯度:99% HPLC 包装信息:5KG;1KG
  •  
  • 公司名称:湖北巨胜科技有限公司
  • 联系电话:North:18871490274,QQ:1400878000 South:18871490354,QQ:1400868000
  • 产品介绍: CAS:309712-55-8
  •