基本属性 生物活性体外研究 用途与合成方法 供应商
网站主页  化工产品目录 生物化工  抑制剂  神经信号通路(Neuronal Signaling)  P2 Receptor 抑制剂  GW791343 HCl

GW791343 HCl

GW791343 HCl

中文名称:GW791343 HCl
英文名称:GW791343 HCl
CAS号:309712-55-8
分子式:C20H27Cl3F2N4O
分子量:483.8103864
EINECS号:
Mol文件:309712-55-8.mol
GW791343 HCl 结构式

GW791343 HCl 性质

储存条件 Store at -20°C
溶解度 在水中溶解度为 100 mM,在 DMSO 中溶解度为 100 mM
形态 粉末
CAS 数据库 309712-55-8

GW791343 HCl 用途与合成方法

GW791343 HCl是GW791343的盐酸盐形式,是一种非竞争性的人类P2X7 receptor变构抑制剂,pIC50为7。 In cells expressing human P2X7 receptors, GW 791343 inhibits agonist-stimulated ethidium accumulation in both sucrose and NaCl buffer. In NaCl buffer, GW 791343 reduces the maximal response to both ATP and BzATP, but there is little effect on agonist potency except for a decrease in the presence of 300–1000 nM GW 791343. GW 791343 also reduces maximal responses to ATP and BzATP in sucrose buffer, although this effect is more marked when using ATP as agonist. In sucrose buffer, GW 791343 produces a slight decrease in ATP potency at 300 nM. GW 791343 decreases BzATP potency at concentrations of 300 nM to 10 μM. A more marked increase in agonist effect is observed when using ATP as agonist in NaCl buffer with GW791343 increasing the pEC50 and maximal response to ATP at concentrations of 10 and 30 μM. In sucrose buffer, GW791343 also increases responses when using ATP as agonist. GW791343 inhibits responses at the human–rat chimeric receptor in both sucrose and NaCl buffer. GW791343 increases responses to BzATP at the F95L mutant receptor. GW791343 is a non-competitive antagonist and negative allosteric modulator at the human P2X7 receptor; however, GW 791343 also acts as a positive allosteric modulator at the rat P2X7 receptor. At the dog P2X7 receptor, GW 791343 is an antagonist with similar potency to that determined at the human receptor.

GW791343 HCl供应商 更多

上海阿拉丁生化科技股份有限公司
联系电话:400-6206333 18521732826;
产品介绍:
英文名称:GW791343 HCl
CAS:309712-55-8
纯度:99%
包装信息:4692RMB/10MG
备注:试剂级
广州和为医药科技有限公司
联系电话: 18620099427
产品介绍:
英文名称:GW791343 HCl
CAS:309712-55-8
纯度:99%
包装信息:1MG;2.5MG;5MG;10MG;25MG
上海一飞生物科技有限公司
联系电话:021-65675885 18964387627
产品介绍:
英文名称:GW 791343 hydrochloride
CAS:309712-55-8
纯度:98%
包装信息:10mg
备注:试剂级
成都点纯科技有限公司
联系电话:400-1166-196 18502815961
产品介绍:
英文名称:GW791343 HCl
CAS:309712-55-8
纯度:99% HPLC
包装信息:10g;50g;100g;500g;1kg;5kg;25kg
苏州爱玛特生物科技有限公司
联系电话:0512-56316828
产品介绍:
英文名称:GW 791343 hydrochloride
CAS:309712-55-8
纯度:97% HPLC
包装信息:5g;25g;100g;1kg