2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)
英文名称:2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
CAS号:112898-15-4
分子式:C30H39N6O15P3
分子量:816.58
EINECS号:
Mol文件:112898-15-4.mol
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | DMSO 中≤14 mg/ml |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 5mM) |
| InChIKey | HVOVBTNCGADRTH-WBLDMZOZSA-N |
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) 用途与合成方法
BzATP triethylammonium salt 是一种 P2X 受体激动剂，对 P2X1，P2X2，P2X3，P2X2/3，P2X4 和 P2X7 的 pEC50 分别为 8.74，5.26，7.10，7.50， 6.19，6.31 和 5.33。BzATP triethylammonium salt 对 P2X7 受体有效，对大鼠 P2X7 和小鼠 P2X7 的EC50 分别为 3.6 μM 和 285 μM。
pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)
BzATP (10-1000 μM; 24 h) promotes the proliferation and migration of U87 and U251 glioma cells.
P2X7R protein expression is induced by BzATP (100 μM; 6-48 h) in human glioma cells.
Cell Proliferation Assay
| Cell Line: | U87 and U251 glioma cells |
| Concentration: | 5, 10, 50, 100, 500 and 1000 μM |
| Incubation Time: | 2, 6, 12, 24, 48 and 72 hours |
| Result: |
The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000 uM and 100-1000 μM, respectively.
The peak of cell proliferation of both U87 and U251 cell lines was at 100 μM. The optimal incubation time is 24 hours in both U87 and U251 cells lines. |
Western Blot Analysis
| Cell Line: | U87 and U251 glioma cells |
| Concentration: | 100 μM |
| Incubation Time: | 6-48 hours |
| Result: | Induced the upregulation of P2X7R. |
BzATP (5 mg/kg) significantly promotes P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction.
| Animal Model: | Male 2-month-old C57BL/6 mice (each weighing between 20 and 25 g) |
| Dosage: | 5 mg/kg |
| Administration: | Injected through the intraperitoneal route |
| Result: | At 48 hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively. |
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-136254 | 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) | 112898-15-4 | 5mg | 1200 |
| 2024-11-08 | HY-136254 | 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) | 112898-15-4 | 10mg | 1900 |
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)供应商 更多
南京沛微生物科技有限公司
黄金产品
联系电话：025-57027729 15850702895
产品介绍：
中文名称：2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C);2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐
英文名称：BENZOYLBENZOIC ADENOSINE 5'-TRIPHOSPHATE;2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT;2'-3'-O-(4-benzoylbenzoyl)adenosine*5'-triphospha;2'-3'-O-(4-BENZOYLBENZOYL)ADENOSINE5'-TR IPHOSPHATE;2'(3')-o-(4-benzoylbenzoyl)adeno
CAS：112898-15-4
纯度：95%HPLC
包装信息：1mg;10mg;1g;10g;100g
备注：试剂级
武汉易泰科技有限公司上海分公司
联系电话：821-50328103-801 18930552037
产品介绍：
中文名称：2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)
英文名称：BzATP triethylaMMoniuM salt;2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphatetri(triethylaMMoniuM)salt
CAS：112898-15-4
纯度：99% HPLC
包装信息：1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
联系电话：021-61415566 800-8193336
产品介绍：
英文名称：2'(3')-O-(4-Benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt
CAS：112898-15-4
纯度：>=93%
包装信息：5MG
备注：B6396-5MG
江苏艾康生物医药研发有限公司
联系电话：025-66028182 18112977050
产品介绍：
英文名称：2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
CAS：112898-15-4
纯度：95+%
包装信息：1g;5g;10g
江苏艾康生物医药研发有限公司
联系电话：025-66113011 18112977050
产品介绍：
英文名称：2- AND 3-O-(4-BENZOYLBENZOYL)-ADENOSINE 5-TRIPHOSPHATE TRIETHYLAMMONIUM SALT
CAS：112898-15-4
纯度：95% HPLC or GC
包装信息：10G,5G;1G
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