17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid (AEEA-AEEA) is a Semaglutide intermediate used in the preparation of glutamate-containing acylation reagents, as well as in the selective acylation of amino groups in peptides or proteins.
At room temperature, AEEA-AEEA is typically a white to off-white crystalline powder with a melting point of 133 to 135 °C. Its predicted boiling point is approximately 548.7 °C, and its predicted density is approximately 1.202 g/cm³. This compound has some solubility in dimethyl sulfoxide (DMSO) and methanol, but the solubility is low and usually requires heating or ultrasonic treatment.
17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid is used for preparation of glutamic acid-containing acylating reagents for selective acylation of amino group(s) in peptides or proteins.
AEEA-AEEA has significant application value in the field of targeted drug development, especially in the synthesis of antibody-drug conjugates (ADCs). As a non-cleavable linker, it can be used to link antibodies and cytotoxic drugs to improve drug stability and targeting.
17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic Acid is synthesized by Hydrolysis Reaction of 12,12-Dimethyl-10-oxo-3,6,11-trioxa-9-azatridecanoic acid with Hydrolysis Reaction in Dichloromethane for 2h.
