CGP 60474 is type of protein kinase C inhibitor (ckd1/cdk2) used in the treatment of different cancers
ChEBI: 3-[[4-[2-(3-chloroanilino)-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol is a substituted aniline.
CGP-60474 (10mg/kg; i.p.) inhibits the IL-6 level and increases the survival rate in the LPS endotoxemia model[2].
| Animal Model: | C57Bl/6 mice (LPS endotoxemia model)[2] |
| Dosage: | 10mg/kg |
| Administration: | I.p. |
| Result: | Had a higher survival rate.
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CDK1-Cyclin B: 26 nM (IC50); CDK2/cyclinE: 3 nM (IC50); cdk2/cyclin A: 4 nM (IC50); CDK4/cyclin D: 216 nM (IC50); Cdk5/p25: 10 nM (IC50); CDK7/cyclin H: 200 nM (IC50); CDK9/cycT: 13 nM (IC50); PKC
![3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol Structure](/CAS2/GIF/164658-13-3.gif)
![3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/195c9f28-d032-4cb8-93a7-5b545100274c.png)
![3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/05807918-a940-4db2-85de-a64952392ec4.jpg)