3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol

Name

3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol

Synonym

More Synonyms

Description

CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor.

Related Catalog

Target

VEGFR-2:84 nM (IC50)

PKC

In Vitro

CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM[1]. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP[2].

References

[1]. Kuo GH, et al. Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors. J Med Chem. 2005 Jul 14;48(14):4535-46.

[2]. Stanetty P, et al. Novel and efficient access to phenylamino-pyrimidine type protein kinase C inhibitors utilizing a Negishi cross-coupling strategy. J Org Chem. 2005 Jun 24;70(13):5215-20.

Density

1.356g/cm3

Boiling Point

630.6ºC at 760mmHg

Molecular Formula

C18H18ClN5O

Molecular Weight

355.82100

Flash Point

335.2ºC

Exact Mass

355.12000

PSA

86.19000

LogP

3.22480

Vapour Pressure

9.02E-17mmHg at 25°C

Index of Refraction

1.685

GNF-Pf-88

1-Propanol,3-((4-(2-((3-chlorophenyl)amino)-4-pyrimidinyl)-2-pyridinyl)amino)

UNII-16IP6G5MLC

CGP60474