磷酸哌喹
中文名称:磷酸哌喹
英文名称:4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
CAS号:85547-56-4
分子式:C29H32Cl2N6.H3PO4
分子量:633.51
EINECS号:1312995-182-4
Mol文件:85547-56-4.mol
磷酸哌喹 用途与合成方法
Piperaquine phosphate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.
Piperaquine (90 mg/kg; a single i.p.) exhibits the t
1/2
, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.
| Animal Model: | Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites |
| Dosage: | 0, 10, 30, 90 mg/kg |
| Administration: | A single i.p. administration |
| Result: |
The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg. |
| Animal Model: | Male Swiss mice (6 weeks old) |
| Dosage: | 90 mg/kg (Pharmacokinetic Analysis) |
| Administration: | A single i.p. administration |
| Result: | t 1/2 =17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
磷酸哌喹 化学药品说明书
磷酸哌喹供应商 更多
南京艾瑞博生物科技有限公司
现货
联系电话： 19951442182
产品介绍：
中文名称：磷酸哌喹
英文名称：4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
CAS：85547-56-4
纯度：97%
包装信息：g;kg
库存量：662.8g
现货日期：2024/12/15 17:55:19
湖北魏氏化学试剂股份有限公司
新品
联系电话：027-59102966 18717199209
产品介绍：
中文名称：磷酸哌喹
英文名称：Piperaquine phosphate
CAS：85547-56-4
纯度：95-99%HPLC
包装信息：1kg;100g;1g
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上海瀚鸿科技股份有限公司
联系电话：021-54306202 13764082696
产品介绍：
中文名称：磷酸哌喹
英文名称：Piperaquine Phosphate
CAS：85547-56-4
纯度：98%
备注：D72038
