磷酸哌喹
中文名称:磷酸哌喹
英文名称:4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
CAS号:85547-56-4
分子式:C29H32Cl2N6.H3PO4
分子量:633.51
EINECS号:1312995-182-4
Mol文件:85547-56-4.mol
磷酸哌喹 用途与合成方法
Piperaquine phosphate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.
Piperaquine (90 mg/kg; a single i.p.) exhibits the t
1/2
, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.
| Animal Model: | Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites |
| Dosage: | 0, 10, 30, 90 mg/kg |
| Administration: | A single i.p. administration |
| Result: |
The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg. All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg. |
| Animal Model: | Male Swiss mice (6 weeks old) |
| Dosage: | 90 mg/kg (Pharmacokinetic Analysis) |
| Administration: | A single i.p. administration |
| Result: | t 1/2 =17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
磷酸哌喹 化学药品说明书
磷酸哌喹供应商 更多
铭龙（咸宁）医药有限公司
新品
联系电话：155-7155-6913 15571556913
产品介绍：
中文名称：磷酸哌喹
英文名称：4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
CAS：85547-56-4
纯度：99%
包装信息：1kg;25kg;100kg
备注：铭龙主要产品优势：医药中间体,多肽,植物提取物,化工原料,1G 10G 100g 1KG 25KG 100KG 500KG 按需求包装 现货当天发货,王经理 联系电话：15571556913(微信同号)QQ：354024111
上海瀚鸿科技股份有限公司
联系电话：021-54306202 13764082696
产品介绍：
中文名称：磷酸哌喹
英文名称：Piperaquine Phosphate
CAS：85547-56-4
纯度：98%
备注：D72038
上海昕凯医药科技有限公司
联系电话：21-619849051-1 18521059765
产品介绍：
英文名称：4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)
CAS：85547-56-4
纯度：95%+
包装信息：50g,500g,10kg or as request
