2,4-Dichlorophenylacetonitrile

773837-37-9

94-99-5

6306-60-1

General method: 2,4-dichlorobenzyl chloride (1.0 mmol) was mixed with sodium cyanide (2 mmol) in deionized water (5 mL) and polyethylene glycol modified diisocyanate (PEG-MDIL, 0.2 g) was added. The reaction suspension was placed under reflux conditions and the reaction mixture was stirred using a magnetic stirrer for the reaction time referred to in Table 2.After completion of the reaction, the mixture was extracted with ether (2 × 10 mL). The organic extracts were combined, dried with anhydrous calcium chloride and subsequently concentrated under reduced pressure. By this method, the target product 2,4-dichlorophenylacetonitrile was obtained in good to excellent isolated yields (see Scheme 3).