C3A (70-77),ASHLGLAR
C3A (70-77),ASHLGLAR 性质
| 密度 | 1.44±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | −20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 3.34±0.10(Predicted) |
| 序列 | Ala-Ser-His-Leu-Gly-Leu-Ala-Arg |
C3A (70-77),ASHLGLAR 用途与合成方法
Complement system
The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10
-7
M or higher and exceeds 75% at 10
-6
M, irrespective of the stimulus.
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites.
