Piperidine-1-sulfonyl chloride

110-89-4

35856-62-3

Example 1: Synthesis of piperidine-1-sulfonyl chloride A mixture of piperidine (100 g, 1.17 mol) and triethylamine (178 g, 1.76 mol) in dichloromethane (500 ml) was slowly added to a solution of sulfuryl chloride (238 g, 1.76 mol) in dichloromethane (500 ml) at 0 °C - 5 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. After completion of the reaction, the mixture was quenched by pouring into ice water. The organic layer was separated and washed with distilled water (2 x 5 v/v). The organic layer was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give an oily residue (151.3 g, 70% yield). The resulting product was characterized by nuclear magnetic resonance hydrogen spectroscopy (H NMR): H NMR (300 MHz, CDCl3) δ = 1.58-1.62 (m, 2H), 1.69-1.83 (m, 4H), 3.31-3.42 (m, 4H).