AGN 194310

Product NameAGN 194310
CAS229961-45-9
MFC28H24O2S
MW424.55
EINECS
MOL File229961-45-9.mol

Chemical Properties

Boiling point	598.1±50.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	>16.8mg/mL in DMSO
form	Powder
pka	4.02±0.10(Predicted)
color	White to off-white

Usage And Synthesis

Biological Activity

AGN 194310 (VTP-194310) is a high-affinity, potent, and selective pan-antagonist of retinoic acid receptors (RARs) with Kd values of 3 nM and 2 nM for RARα, RARβ, and RARγ, respectively , 5 nM.

in vivo

AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte -progenitor cells are observed in the bone marrow of mice after treatment with AGN194310.

Animal Model:	Female C57Bl/6J mice (Five -week-old (34-37 days))
Dosage:	0.5 mg/kg/ day
Administration:	Oral gavage; every day; for 10 days
Result:	The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly.

target

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RARα

3 nM (Kd)

RARβ

2 nM (Kd)

RARγ

5 nM (Kd)