AGN 194310
- Product NameAGN 194310
- CAS229961-45-9
- CBNumberCB01346990
- MFC28H24O2S
- MW424.55
- MOL File229961-45-9.mol
Chemical Properties
| Boiling point | 598.1±50.0 °C(Predicted) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | >16.8mg/mL in DMSO |
| form | Powder |
| pka | 4.02±0.10(Predicted) |
| FDA UNII | V2W3I5K9O0 |
AGN 194310 Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| Sigma-Aldrich SML2665 | 5MG | $123 | AGN194310 ≥98% (HPLC) |
Buy |
| Sigma-Aldrich SML2665 | 25MG | $495 | AGN194310 ≥98% (HPLC) |
Buy |
| ApexBio Technology B4702 | 5mg | $500 | AGN194310 |
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| ApexBio Technology B4702 | 10mM(in 1mL DMSO) | $514 | AGN194310 |
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| ApexBio Technology B4702 | 1mg | $158 | AGN194310 |
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AGN 194310 Chemical Properties,Usage,Production
Biological Activity
AGN 194310 (VTP-194310) is a high-affinity, potent, and selective pan-antagonist of retinoic acid receptors (RARs) with Kd values of 3 nM and 2 nM for RARα, RARβ, and RARγ, respectively , 5 nM.in vivo
AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte -progenitor cells are observed in the bone marrow of mice after treatment with AGN194310.
| Animal Model: | Female C57Bl/6J mice (Five -week-old (34-37 days)) |
| Dosage: | 0.5 mg/kg/ day |
| Administration: | Oral gavage; every day; for 10 days |
| Result: | The number of granulocytes was significantly increased across haemopoietic compartments. Progenitor cells containing granulocytes also increased significantly. |
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