1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
英文名称:1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
CAS号:511-26-2
分子式:C22H34O2
分子量:330.5
EINECS号:
Mol文件:511-26-2.mol
![1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 结构式](https://img.chemicalbook.com/CAS/GIF/511-26-2.gif)
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 性质
| 熔点 | 123.5° |
|---|---|
| 比旋光度 | D18 +18° (c = 1.085 in chloroform) |
| 沸点 | 426.6±45.0 °C(Predicted) |
| 密度 | 1.04±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：25 mg/mL（75.64 mM） |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 用途与合成方法
MAP4343 是 Pregnenolone 的 3-甲基醚衍生物。MAP4343 在体外与微管相关蛋白 2 (MAP2) 结合，刺激微管蛋白的聚合，增强神经突的延伸并保护神经元免受神经毒性剂的侵害。
MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro.
MAP4343 (30 μM; 2-8 d) stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.
MAP4343 (20 μM; 1 h) protects against microtubule depolymerization induced by Nocodazole in PC12 cells
MAP4343 (12 mg/kg; daily s.c. for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases MAP2 levels in spinal cord after SCI in rats.
MAP4343 (4 mg/kg; daily s.c. for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats.
| Animal Model: | Adult Sprague-Dawley male rats with spinal cord injury |
| Dosage: | 12 mg/kg |
| Administration: | Daily s.c. for 28 days |
| Result: |
Increased the number of animals able to walk with weight-supported plantar steps.
Showed forelimb-hindlimb coordination at the end of the study. |
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-11-08 | HY-107116 | 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone | 511-26-2 | 5mg | 1000 |
| 2024-11-08 | HY-107116 | 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone | 511-26-2 | 10mM * 1mLin DMSO | 1100 |
1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone供应商 更多
上海一飞生物科技有限公司
联系电话：021-65675885 18964387627
产品介绍：
英文名称：MAP4343
CAS：511-26-2
纯度：99.00%
包装信息：1mg;2mg;5mg
备注：试剂级
医恩医疗系统研发(上海)有限公司
联系电话：021-58958002 18930822973
产品介绍：
英文名称：PME
CAS：511-26-2
纯度：98% LC-MS
包装信息：10g, 50g, 100g, 1Kg
上海传芊化工科技中心
联系电话： 15869524721
产品介绍：
英文名称：MAP4343
CAS：511-26-2
纯度：98% HPLC
包装信息：5MG;10MG;50MG;100MG,1G,5G,10G
成都超九八生物科技有限公司
联系电话：13348960310 13348960310
产品介绍：
英文名称：PME
CAS：511-26-2
纯度：>=98%
包装信息：5mg10mg20mg0mg100mg00mg1g2g等应客户需求包装
