Lithium aluminum hydride (LAH, 0.54 g, 14.2 mmol) was added to a tetrahydrofuran solution of 5-(azidomethyl)-2-(trifluoromethyl)pyridine (2.6 g, 12.86 mmol) at -78 °C. The resulting mixture was stirred for 15 minutes, then heated to room temperature and reacted for another hour. The reaction was then quenched with a saturated aqueous solution of ammonium chloride, and stirred for several hours. Anhydrous sodium sulfate was added to the system to separate the two phases into clear layers. The residue was washed with ethyl acetate after filtration. The organic phases were combined and concentrated to give 3-aminomethyl-6-(trifluoromethyl)pyridine.
3-Aminomethyl-6-(trifluoromethyl)pyridine is an important heterocyclic intermediate in the field of drug synthesis, mainly used in the synthesis of antimalarial drugs, kinase inhibitors, anti-inflammatory drugs, etc.
