ABT-263

• Product Name:ABT-263
• Synonyms: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide ABT 263 BenzaMide, 4-(4-((2-(4-chlorophenyl)-5,5-diMe Benzamide, 4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-N-((4-(((1R)-3-(4-morpholinyl)-1-((phenylthio)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)- ABT-263,Navitoclax (S)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide ABT-26 ABT 263 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
• CAS:923564-51-6
• MF:C47H55ClF3N5O6S3
• MW:974.61
• EINECS:
• Mol File:923564-51-6.mol
• 

ABT-263 is structurally related to ABT-737; it is a disruptor of Bcl-2/Bcl-xL interactions with pro-apoptotic proteins. Overexpression of the prosurvival Bcl-2 family members is commonly associated with tumor maintenance, progression, and chemoresistance. [1] ABT-263 displays the protection afforded by overexpression of Bcl-2 or Bcl-xL with EC50 values of 60 nM and 20 nM, respectively. A wide range of cellular activity is observed with ABT-263 having a 50% growth inhibition (EC50) of 110 nM against the most sensitive line (H146), whereas its activity in the least sensitive line (H82) results in an EC50 at 22 μM. All four cell lines with EC50 values of <400 nM (H146, H889, H1963, and H1417) are also highly sensitive to ABT-737, and the two most resistant lines (H1048 and H82) are similarly resistant to ABT-263.

• Company Name:Lanzhou HuaHao Pharmaceutical Co., Ltd.
• Tel: 18189674620
• Products Intro:Product Name:ABT 263
  CAS:923564-51-6
  Purity:97 Package:1g 50g 200gandmore More...
• CB Index:55
• Related Information:Catalog(489)

• Company Name:Guangzhou Isun Pharmaceutical Co., Ltd
• Tel:020-39119399 18927568969
• Products Intro:Product Name:Navitoclax(ABT-263)
  CAS:923564-51-6
  Purity:98.0% Package:1G; 25G; 1KG; 25KG More...
• CB Index:55
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• Company Name:Zhengzhou HSH Science & Technology Co., Ltd.
• Tel:0371-55932928 18937192232
• Products Intro:Product Name:4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide;ABT 263;Navitoclax
  CAS:923564-51-6
  Purity:0.98 Package:5mg;10mg;100mg;250mg;500mg;1g;5g;10g;25g;50g;100g;250g;500g;1kg;大量 More...
• CB Index:55
• Related Information:Catalog(491)

• Company Name:Hunan Huayi Zhide Pharmaceutical Technology Co., Ltd.
• Tel: 17752881701
• Products Intro:Product Name:Navitoclax
  CAS:923564-51-6
  Purity:99 Package:1G/;10G/
• CB Index:58
• Related Information:Catalog(111)

• Company Name:TargetMol Chemicals Inc.
• Tel:021-021-33632979 15002134094
• Products Intro:Product Name:Navitoclax
  CAS:923564-51-6
  Purity:99.67% Package:1mg/RMB 233;5mg/RMB 535;10mg/RMB 797 More...
• CB Index:58
• Related Information:Catalog(7783)

• Company Name:Shanghai Chaolan Chemical Technology Center
• Tel:021-QQ：65489617 15618227136
• Products Intro:Product Name:ABT 263
  CAS:923564-51-6
  Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G More...
• CB Index:58
• Related Information:Catalog(7268)

• Company Name:Shanghai Aladdin Biochemical Technology Co.,Ltd.
• Tel: +86-18521732826
• Products Intro:Product Name:ABT-263
  CAS:923564-51-6
  Purity:>=98% Package:25mg/RMB 759.90;5mg/RMB 349.90;100mg/RMB 2219.90
• CB Index:58
• Related Information:Catalog(48461)